A multidisciplinary team of researchers from UCL, the University of Cambridge and the University of Sheffield, have recently published a study in Nature Neuroscience linking a Parkinson’s disease-causing mutation in the Fbx07 gene with mitophagy.

Mitochondria are essential cell organelles responsible for producing most of the cell’s energy. They are especially important in nerve cells where the demand for energy is particularly high. When mitochondria fail to function effectively they become cytotoxic. However, cells have developed a mechanism to digest these dysfunctional mitochondria called mitophagy. This study reinforces the idea that non-efficient clearance of dysfunctional mitochondria is causing brain cells’ death in Parkinson’s patients and highlights mitophagy as a target for future therapeutic approaches in Parkinson’s disease. Please click here to read the full article.

Mitochondrial function is of particular interest to The Cure Parkinson's Trust - please click here to read details of our research in this field .