Each day in December we take a look back over our year - it has been one of loss and one of enormous change but above all it has been one of hopefulness, of inspiration, huge determination and focus.

We are grateful to each and every one of you for your support and engagement this year - in steering groups, science meetings and participating in pioneering trials; for your fundraising efforts and for your encouragement.

Sit back and... Welcome to our Advent Calendar.